National airlines:

Aer Lingus
The Irish airlines provide direct flights to Prague from Dublin. Flights with layovers from other cities in Ireland might be available according to the time of year: for more information inquire at your local airport or check for schedules on the airlines official webpage: www.aerlingus.com

British Airways
The British company provides direct flights from London Heathrow to Prague, as well as numerous flights from other departure cities all over the world in partnership with other airlines. Please turn to your local airport for detailed information on flights or check flight schedules on the British Airways website: www.britishairways.com

Czech Airlines
The Czech company offers direct flights from various large European cities, from New York/JFK and from Toronto, among others. Flights from other cities in the USA, Canada and Asia are also available with a (or several) layover. Please check flight schedules on the Czech Airlines website: www.czechairlines.com

Turkish Airlines
The Turkish company offers flights with a layover in Istanbul from New Delhi and Mumbai. Please turn to your local airport for detailed information on flights or check flight schedules on the Turkish Airlines: www.turkishairlines.com

Low cost airlines:

Low cost companies provide direct low cost flights. Safety measures are the same as for national airlines, the difference concerns mainly the standard of services offered to the passengers (extra cost for on-board beverages, for carry-ons,...). These companies often provide special offers, it is thus worth it to check their respective webpage to find the best price.

From the UK and Ireland:
bmibaby (flights from Belfast, Birmingham, East Midlands, Manchester)

Easyjet (flights from Bristol, London/Gatwick, London/Stansted, Nottingham/East Midlands)

jet2 (flights from Edinburgh, Leeds)

Ryanair (flights from Dublin, Birmingham)

Wizzair (flights from Liverpool, London/Luton)